Opioid Information & Treatment Resources

What Are Opioids?

Opioids include illegal drugs such as heroin, as well as prescription medications used to treat pain such as morphine, codeine, methadone, oxycodone (OxyContin®, Percodan®, Percocet®), hydrocodone (Vicodin®, Lortab®, Norco®), fentanyl (Duragesic®, Fentora®), hydromorphone (Dilaudid®, Exalgo®), and buprenorphine (Subutex®, Suboxone®). Opioids work by binding to specific receptors in the brain, spinal cord, and gastrointestinal tract. In doing so, they minimize the body's perception of pain. However, stimulating the opioid receptors or reward centers in the brain can also trigger other systems of the body, such as those responsible for regulating mood, breathing, and blood pressure.

How Does Overdose Occur?

A variety of effects can occur after a person takes opioids, ranging from pleasure to nausea, vomiting, severe allergic reactions (anaphylaxis), and overdose, in which breathing and heartbeat slow or even stop. Opioid overdose can occur when a patient deliberately misuses a prescription opioid or an illicit drug such as heroin. It can also occur when a patient takes an opioid as directed, but the prescriber miscalculated the opioid dose or an error was made by the dispensing pharmacist, or the patient misunderstood the directions for use. Death following opioid use can be prevented with basic life support and a timely administration of the drug Naloxone which would reverse the effect of an opioid overdose if given in time.

Lifesaving Naloxone

Overdose Signs and Symptoms

A combination of these three signs and symptoms may indicate an opioid overdose due to the effects of the opioids on the part of the brain that regulates breathing.

  • pinpoint pupils;
  • unconsciousness; and
  • difficulties with breathing

Tolerance

Tolerance develops when someone uses an opioid drug regularly so that their body becomes accustomed to the drug and needs a larger or more frequent dose to continue to experience the same effect. Loss of tolerance occurs when someone stops taking an opioid after long-term use. When someone loses tolerance and then takes the opioid drug again, they can experience serious adverse effects, including overdose, even if they take an amount that caused them no problem in the past.

Source: Brunswick County Opioid Addiction Task Force. (2017). Facts For Community Members.

World Health Organization. (2021). Opioid Overdose. https://www.who.int/news-room/fact-sheets/detail/opioid-overdose